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Study identifier: NCT06671054 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Dose Response Study to Evaluate the Efficacy and Safety of Oral AP1189 Administered in Disease-Modifying Anti-Rheumatic Drug (DMARD) naïve Participants Participants With Early Rheumatoid Arthritis

Condition: Rheumatoid Arthritis (RA)  ·  Sponsor: SynAct Pharma Aps

PhasePhase 2
Planned participants240
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The study is a randomized, double blind, placebo-controlled, dose response, phase II, multicentre trial to evaluate the efficacy and safety of oral AP1189 administered at the doses of 40, 70, or 100 mg for 12 weeks in combination with methotrexate, in DMARD-naïve participants with early rheumatoid arthritis and active inflammation.

This description comes directly from the study's public registry record.

Talk to the study team

Thomas Jonassen, MD  ·  +45 4015 6669  ·  tj@synactpharma.com

Always discuss trial participation with your own doctor first.

Locations (11)

Nouvelle Clinical Research LLCCutler Bay, Florida, United StatesRecruiting
Millennium Medical Research LLCMiami, Florida, United StatesRecruiting
Altoona Center for Clinical ResearchDuncansville, Pennsylvania, United StatesRecruiting
Diagnostic Consultative Center AleksandrovskaSofia, BulgariaRecruiting
Medical Center Tera MedicoVratsa, BulgariaRecruiting
Sanos Clinic HerlevHerlev, DenmarkRecruiting
IMSP Spitalul Clinic Municipal "Sfanta Treime"Chisinau, MoldovaRecruiting
M2MmedChorzów, PolandRecruiting
Vita Longa Sp. z o. o.Katowice, PolandRecruiting
Medyczne Centrum HetmańskaPoznan, PolandRecruiting
DC-MED Michal Kowalski S.K.Swidnica, PolandRecruiting

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Source record: clinicaltrials.gov/study/NCT06671054