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Study identifier: NCT06671015 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure

Condition: Systolic Heart Failure · Respiratory Failure  ·  Sponsor: Yale University

PhaseNA
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This prospective, open-label randomized controlled pilot trial will enroll participants at the Yale New Haven Hospital. Patients with systolic heart failure, defined as an ejection fraction ≤40%, who require invasive mechanical ventilation (IMV) and are admitted to either the cardiac intensive care unit (CICU) or medical ICU (MICU) will be included. Subjects meeting eligibility criteria will be randomized 1:1 to one of the two treatment groups: * Intervention: Extubation to high-flow nasal cannula (HFNC) * Control: Extubation to non-invasive ventilation (NIV)

This description comes directly from the study's public registry record.

Talk to the study team

Elliott Miller, MD, MS  ·  203-737-6390  ·  elliott.miller@yale.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Yale New Haven Hospital (CICU or MICU)New Haven, Connecticut, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06671015