Condition: Syndecan 1 · Severe Burn · Endotheliopathy of Trauma · Sponsor: Hospital Universitari Vall d'Hebron Research Institute
The purpose of this observational study is to examine whether Endotheliopathy of Trauma (EoT) is present in severely burned patients and how it is affected by burn debridement surgery. The main questions it aims to answer are: * Do severely burned patients present with EoT before undergoing burn debridement surgery? * Does the surgical intervention worsen EoT, leading to increased postoperative syndecan 1 (sdc 1) levels compared to preoperative levels? Participants will: * Undergo debridement surgery where the total area of debrided and donor sites covers 20% or more of the Total Body Surface Area (TBSA). * Have their sdc 1 levels measured before and after surgery. * Have perioperative factors analyzed to assess their impact on endothelial damage and glycocalyx functionality. This study aims to provide insight into how surgical resuscitation affects the endothelial glycocalyx in severely burned patients.
This description comes directly from the study's public registry record.
Laura Pons Pellicé, MD · +34 626498575 · laura.pons@vallhebron.cat
Luis Abarca Vilchez, MD, PhD · +34 661968807 · luis.abarca@vallhebron.cat
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| Hospital Universitari Vall d'Hebron | Barcelona, Spain, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06670248