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Study identifier: NCT06669949 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Natural History of Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS)

Condition: Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS)  ·  Sponsor: University of California, San Francisco

PhaseN/A
Planned participants28
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

This is a prospective longitudinal natural history study with a retrospective cross-sectional arm aimed at determining the natural history of sphingosine phosphate lyase insufficiency syndrome (SPLIS), a recently recognized inborn error of metabolism. The central hypothesis is that age of onset, other disease features, and disease biomarkers will be predictive of quality of life (QOL) and survival in SPLIS patients.

This description comes directly from the study's public registry record.

Talk to the study team

Julie D Saba, MD, PhD  ·  510-414-6317  ·  Julie.Saba@ucsf.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of California San FranciscoSan Francisco, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06669949