Condition: Axial Spondyloarthrithis · Inflammatory Diseases · Arthritis · Sponsor: Loughborough University
The goal of this randomised controlled trial study is to investigate whether exercise (brisk walking, equal to 13 on a rating of perceived exertion scale; somewhat hard) can be used as an adjuvant therapy for people living with axial spondyloarthritis and taking biologic medications to further improve their quality of life and lower their symptoms and disease burden. The main questions it aims to answer are: Does a 12-week structured home-based aerobic exercise intervention have a favourable effect on markers of immune-mediated inflammation and symptom severity? As a secondary aim and outcome, this study will investigate: * The acceptability of this intervention using questionnaires with free text boxes and one-to-one semi-structured interviews in a subset (50%) of participants (Q-ExTASI-B substudy). * The effect of the home-based intervention on circulating markers of cardiometabolic health, anthropometrical measures, and immune markers that associate with systemic inflammation. * The effect of the home-based intervention on objective measures of physical function and exercise tolerance The study will compare the data of a healthy group with that of people living with axial spondyloarthritis. Within the patient population, 20 of the individuals will be allocated to the exercise group (randomly), and 20 will be allocated to the usual care group. In the exercise group, participants will be asked to do 30 minutes of brisk walking five days a week for 12 weeks, and they will…
This description comes directly from the study's public registry record.
Nicolette C Bishop, PhD · 01509226385 · N.C.Bishop@lboro.ac.uk
Matthew J Roberts, PhD · M.Roberts3@lboro.ac.uk
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| Loughborough University, National Centre for Sport and Exercise Medicine | Loughborough, Leicestershire, United Kingdom | Recruiting |
| University Hospitals of Leicester NHS trust | Leicester, United Kingdom, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06669702