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Study identifier: NCT06667700 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

Condition: Coronavirus Disease (COVID-19)  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants3082
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Researchers are looking for other ways to prevent severe illness from COVID-19. COVID-19 is a virus that most often causes mild flu or cold-like symptoms. However, people with certain health conditions or other factors have a high risk (chance) of getting severely ill from COVID-19, which can require a hospital stay or lead to death. Some people who are high risk for severe illness may be unable to take certain treatments for COVID-19 because they are not available to them, or they take other medicines that may react with a treatment and cause an unwanted effect. Molnupiravir (MK-4482) is a study medicine designed to stop the COVID-19 virus from copying itself in the body (multiplying). The goal of this study is to learn if molnupiravir prevents severe illness from COVID-19 more than placebo in people who are high risk.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (224)

Cullman Clinical Trials ( Site 3813)Cullman, Alabama, United StatesCompleted
Helios Clinical Research ( Site 3826)Paradise Valley, Arizona, United StatesRecruiting
Absolute Clinical Research ( Site 3709)Phoenix, Arizona, United StatesActive Not Recruiting
Clinica de Salud del Valle de Salinas ( Site 3825)Castroville, California, United StatesRecruiting
Ascada Health PC dba Ascada Research ( Site 3750)Fullerton, California, United StatesCompleted
Pacific Clinical Studies ( Site 3827)Los Alamitos, California, United StatesRecruiting
Valley Clinical Trials, Inc. ( Site 3707)Northridge, California, United StatesRecruiting
FOMAT Medical Research ( Site 3720)Oxnard, California, United StatesRecruiting
Paradigm Clinical Research, LLC ( Site 3785)San Diego, California, United StatesRecruiting
Optimus Medical ( Site 3817)San Francisco, California, United StatesRecruiting
Millennium Clinical Trials ( Site 3758)Westlake Village, California, United StatesRecruiting
Paradigm Clinical Research Centers, Inc ( Site 3718)Wheat Ridge, Colorado, United StatesRecruiting

+ 212 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06667700