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Study identifier: NCT06666621 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Endogenous Opioid Response to Injections

Condition: Low Back Pain · Zygapophyseal Joint Arthritis  ·  Sponsor: Middle Tennessee Research Institute

PhasePhase 4
Planned participants33
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will study pain relief after spine injections that are used to guide care. Some improvements in pain from a procedure might be from placebo effect rather than the physiological effect of the procedure. The study will use naloxone to reverse the effect of the body's internal placebo system after a spine injection, so the placebo effect and the injection effect can be measured separately. This process may improve the understanding of spine injections and their ability to guide pain care.

This description comes directly from the study's public registry record.

Talk to the study team

William E Rivers, DO  ·  859-513-9793  ·  william.rivers@va.gov

Always discuss trial participation with your own doctor first.

Locations (1)

VA Tennessee Valley Healthcare SystemNashville, Tennessee, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06666621