Condition: Stroke · Hypothermia Treatment · Sponsor: Capital Medical University
Endovascular Thrombectomy has emerged as a pivotal treatment modality for acute ischemic stroke. However, despite successful thrombus removal, a substantial proportion of patients still experience poor outcomes. Selective intra-arterial cooling has shown promise in decelerating stroke progression and providing neuroprotection. This study aims to identify biomarkers associated with the combination of selective intra-arterial cooling infusion and endovascular thrombectomy in the treatment of ischemic stroke by integrating proteomics and metabolomics data. Our study is based on the multicenter RCT study "Safety and Efficacy of Selective Intra-Arterial Cooling Infusion Combined With EVT in Acute Ischemic Stroke." All samples were derived from this experiment. Our objective is to elucidate the molecular mechanisms underlying the prognostic impact of this combined therapeutic approach, providing insights to optimize stroke treatment strategies.
This description comes directly from the study's public registry record.
Xunming Ji, Professor · +86 17600104266 · chenxi00cx@126.com
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| Dalian Municipal Central Hospital | Dalian, Liaoning, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06665386