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Study identifier: NCT06659445 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD

Condition: Geographic Atrophy (GA) · Age - Related Macular Degeneration (AMD)  ·  Sponsor: ONL Therapeutics

PhasePhase 2
Planned participants324
Who can joinAll sexes, 55 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to collect efficacy and safety information of intravitreal injection for 3 experimental arms, including 2 dose levels of ONL1204 and 2 treatment frequencies in patients with GA associated with AMD. GA associated with AMD is one of the world's leading causes of visual disability and legal blindness globally. Associated with aging, cigarette smoking, obesity, diets low in certain nutrients, a lifestyle related to cardiac risk, and a growing list of genetic factors, AMD is becoming an increasingly prevalent public health concern, especially as the global population ages. ONL1204 is a first-in-class inhibitor of fragment apoptosis stimulator receptor-mediated cell death that has demonstrated protection of multiple retinal cell types in numerous preclinical models of retinal disease, including models of dry AMD.

This description comes directly from the study's public registry record.

Talk to the study team

Study Coordinator  ·  734-412-8787  ·  info@onltherapeutics.com

Always discuss trial participation with your own doctor first.

Locations (57)

Associated Retina ConsultantsGilbert, Arizona, United StatesRecruiting
Associated Retina ConsultantsPhoenix, Arizona, United StatesRecruiting
California Retina ConsultantsBakersfield, California, United StatesRecruiting
Retina-Vitreous Associates Medical GroupBeverly Hills, California, United StatesRecruiting
Macula and Retina InstituteGlendale, California, United StatesRecruiting
Salehi Retina Institute, dba Retina Associates of Southern CaliforniaHuntington Beach, California, United StatesRecruiting
Desert Retina ConsultantsPalm Desert, California, United StatesRecruiting
Retinal Consultants Medical GroupSacramento, California, United StatesRecruiting
Bay Area Retina AssociatesWalnut Creek, California, United StatesRecruiting
Retina Consultants of Southern ColoradoColorado Springs, Colorado, United StatesRecruiting
Retina Group of New EnglandWaterford, Connecticut, United StatesRecruiting
Florida Retina InstituteOrlando, Florida, United StatesRecruiting

+ 45 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06659445