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Study identifier: NCT06657976 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Response to Exercise and Nitric Oxide in PAD

Condition: Peripheral Artery Disease · Exercise · Intermittent Claudication  ·  Sponsor: Northwestern University

PhasePhase 2
Planned participants200
Who can joinAll sexes, 50 Years to no upper limit
Healthy volunteersNo

About this study

RESIST PAD is a randomized trial of 200 PAD patients to establish: 1) whether a 12-week exercise intervention significantly increases Δ nitrite at 12-week follow-up, compared to control; 2) whether exercise "responders" have greater Δ nitrite increases compared to "non-responders"; 3) among non-responders, whether supplementing exercise with nitrate-rich beetroot juice between weeks 13-24 increases Δ nitrite and improves 6-minute walk at 24-week follow-up.

This description comes directly from the study's public registry record.

Talk to the study team

Mary M McDermott, MD  ·  312-503-6419  ·  mdm608@northwestern.edu

Kathryn Domanchuk, BS  ·  312-503-6438  ·  k-domanchuk@northwestern.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Northwestern University Feinberg School of MedicineChicago, Illinois, United StatesRecruiting
University of ChicagoChicago, Illinois, United StatesNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06657976