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Study identifier: NCT06656416 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

ALTO-100 in Bipolar Disorder With Depression (BD-D)

Condition: Bipolar Disorder I or II With a Major Depressive Episode  ·  Sponsor: Alto Neuroscience

PhasePhase 2
Planned participants200
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

The purpose of this study is to assess antidepressant efficacy differences between ALTO-100 and placebo during the Double-Blind period in patients with bipolar disorder I or II with current major depressive episode, when used adjunctively to a mood stabilizer and/or atypical antipsychotic, related to patient characteristics. Additionally, safety, tolerability, and efficacy will be assessed in a subsequent open label treatment period.

This description comes directly from the study's public registry record.

Talk to the study team

Alto Neuroscience  ·  650-200-0412  ·  clinical@altoneuroscience.com

Always discuss trial participation with your own doctor first.

Locations (27)

Site 6036Chandler, Arizona, United StatesWithdrawn
Site 6000Phoenix, Arizona, United StatesRecruiting
Site 6087Yuma, Arizona, United StatesRecruiting
6039Fayetteville, Arkansas, United StatesRecruiting
6070Little Rock, Arkansas, United StatesRecruiting
Site 6081Imperial, California, United StatesRecruiting
6069Los Angeles, California, United StatesRecruiting
Site 6016Mather, California, United StatesNot Yet Recruiting
Site 6082Oceanside, California, United StatesRecruiting
Site 6102Riverside, California, United StatesRecruiting
Site 6112Colorado Springs, Colorado, United StatesNot Yet Recruiting
Site 6067Lauderhill, Florida, United StatesWithdrawn

+ 15 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06656416