Condition: Neonatal Infection · Sponsor: Hospices Civils de Lyon
The management of premature infants hospitalized in neonatal units requires the simultaneous intravenous (IV) infusion of several drugs and parenteral nutrition solutions, when oral administration is impossible or unsuitable. IV administration requires the use of a central venous catheter and an infusion set that connects the catheter to the infusion fluid or drug. The use of multiple infusion devices exposes patients to central line-associated bloodstream infections (CLABSI), drug interactions, abnormal administration timing and repetition of procedures in close proximity to the infant. Against this backdrop, DORAN INTERNATIONAL has developed the EDELVAISS multi-infusion strategy (Multiline Neo® and Escape Line® devices) adapted to neonatology. Given its characteristics, the benefits expected from the use of this strategy are: 1) to reduce the risk of microbial contamination and therefore the number of nosocomial infections 2) reduce exposure to antibiotics used in late sepsis 3) reduce the number of central line losses due to catheter obstruction 4) reduce dys-stimulating procedures in contact with the infant and 5) reduce staff stress. A pilot study before (year 2019) and after (year 2020) was carried out in the tertiary care neonatal unit at Croix-Rousse hospital. The baseline CLABSI rate was slightly below the national level of the last French survey (12.4/1000 catheter days \[95%CI:10.8;14.0\]). In 322 very-low-birth-weight infants, the investigators showed a signific…
This description comes directly from the study's public registry record.
Jean-Charles PICAUD, MD, PhD · 04 72 00 15 50 · jean-charles.picaud@chu-lyon.fr
Fanny JOUBERT · 04 26 73 27 27 · fanny.joubert@chu-lyon.fr
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| Service de néonatologie Hôpital Femme Mère Enfant | Bron, France, France | Recruiting |
| Service Pédiatrie néonatale et réanimations CHU Montpellier | Montpellier, France, France | Not Yet Recruiting |
| Service de néonatologie CHU de Strasbourg | Strasbourg, France, France | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT06656104