Condition: Pancreatic Cancer · EUS-FNB · Intratumoral Microbiota · Sponsor: The Third Xiangya Hospital of Central South University
The goal of this observational study is to use endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) to investigate the intratumoral microbiome profile in patients with pancreatic ductal adenocarcinoma (PDAC) and to evaluate its potential impact on tumor diagnosis and prognosis. PDAC is the most common and lethal type of pancreatic cancer, accounting for over 85% of all pancreatic cancer cases. Given that most patients are diagnosed at an advanced stage when surgery is no longer an option, EUS-FNB serves as a crucial and minimally invasive method for accessing and analyzing the microbiome within the tumor. The main questions this study aims to answer are: Can EUS-FNB reliably and accurately detect the microbiome within PDAC tumors? Researchers will analyze tissue samples obtained through EUS-FNB to confirm its ability to accurately capture the diversity and composition of the tumor microbiome. Are there specific microbes or metabolites within the PDAC tumor microbiome that are linked to patient prognosis or response to chemotherapy? The study will screen for and identify key microbial species or metabolites associated with treatment outcomes and patient survival in PDAC. To ensure the reliability of the EUS-FNB results, researchers will systematically compare microbiome data obtained from EUS-FNB samples with those from surgical biopsies of pancreatic cancer tissue. This comparison will help validate the consistency and accuracy of the two methods in identifying the…
This description comes directly from the study's public registry record.
Li Tian · 0731-13574843423 · f3tianli@outlook.com
Xiayu Mao · 0731-17773669813 · Xiayumoo009@outlook.com
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| The Third Xiangya Hospital of Central South University | Hunan, Hunan, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06655233