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Study identifier: NCT06654882 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Trial of Sequential Medications AfteR TNFi Failure in Juvenile Idiopathic Arthritis

Condition: Polyarticular Course Juvenile Idiopathic Arthritis (JIA)  ·  Sponsor: Duke University

PhasePhase 3
Planned participants400
Who can joinAll sexes, 2 Years to 17 Years
Healthy volunteersNo

About this study

This study is an open-label, randomized, multicenter trial that incorporates a multi-arm design comparing each of 3 non-TNFi (Tumor Necrosis Factor inhibitor) medications to a second TNFi (active control) within a sequential multiple assignment randomized trial design with 2 randomization stages corresponding with clinical decision points. The first randomization addresses whether each of the 3 non-TNFi medications is superior to treatment with a second TNFi. The second randomization allows identification of optimal sequential use of biologics (treatment strategies).

This description comes directly from the study's public registry record.

Talk to the study team

Laura E Schanberg (Contact PI)  ·  919-373-3863  ·  laura.schanberg@duke.edu

Huiman Barnhart (Dual PI)  ·  919-668-8828  ·  huiman.barnhart@duke.edu

Always discuss trial participation with your own doctor first.

Locations (6)

University of California San Francisco Pediatric RheumatologySan Francisco, California, United StatesRecruiting
University of FloridaGainesville, Florida, United StatesRecruiting
Hackensack Meridian Health - Joseph M. Sanzari Children's HospitalHackensack, New Jersey, United StatesRecruiting
Nationwide Children's HospitalColumbus, Ohio, United StatesRecruiting
Asklepios Children's HospitalSankt Augustin, North Rhine-Westphalia, GermanyRecruiting
IRCCS Giannina Gaslini InstituteGenoa, Liguria, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT06654882