Condition: Hailey Hailey Disease · Sponsor: Yale University
Hailey-Hailey disease (HHD) is a debilitating genetic skin disorder, affecting mainly body folds with erythema and painful erosions and blisters. Histopathological findings include epidermal hyperplasia, suprabasilar clefting, dyskeratosis and acantholysis of keratinocytes. A final diagnosis of HHD is usually confirmed based on clinical and histopathological findings in line with genetic testing. Several treatment options have been proposed for this chronic and disabling disorder, however, there is no reproducibly effective therapeutic for it. The primary objective is to evaluate the treatment response of guselkumab. Single-center, non-randomized, single-arm, open-label, phase II trial to evaluate the efficacy and safety of guselkumab for the treatment of patients with HHD.
This description comes directly from the study's public registry record.
Caroline Echeandia-Francis, BA · 203-785-2789 · caroline.francis@yale.edu
Sheila Garcia, BS · 475-321-0545 · Sheila.garcia@yale.edu
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| Church Street Research Unit, Yale Center for Clinical Investigation | New Haven, Connecticut, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06651489