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Study identifier: NCT06649955 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study

Condition: ALS - Amyotrophic Lateral Sclerosis  ·  Sponsor: PathMaker Neurosystems Inc.

PhaseNA
Planned participants15
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

Following completion of the ALS Early Feasibility Study of the MyoRegulator® device for treatment of ALS (NCT06165172), the CALM study will further assess the feasibility of the MyoRegulator® device to treat ALS in an expanded number of individuals with ALS. CALM will gather additional preliminary evidence of clinical safety and potential effectiveness in this patient population with a longer follow-up period and additional secondary endpoints in a single-arm study prior to commencing a larger sham-controlled pivotal trial.

This description comes directly from the study's public registry record.

Talk to the study team

Seward Rutkove (Clinical Site PI), M.D.  ·  617-667-3069  ·  mhemme@bidmc.harvard.edu

Nader Yaghoubi (Study PI), M.D., Ph.D.  ·  617-535-7696  ·  nyaghoubi@pmneuro.com

Always discuss trial participation with your own doctor first.

Locations (1)

Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06649955