Condition: Ischemic Stroke · Small Vessel Cerebrovascular Disease · Cholesterol, LDL · Sponsor: Seoul National University Hospital
Lipid-lowering therapy constitutes a cornerstone of secondary prevention in ischemic stroke; however, current stroke guidelines remain deficient in providing optimal target low-density lipoprotein (LDL)-cholesterol levels tailored to the stroke subtypes. Most clinical trials on LDL-cholesterol management have not differentiated between stroke subtypes or have primarily focused on large artery atherosclerosis (LAA) stroke, leaving a gap in evidence for managing LDL-cholesterol in other stroke subtypes, e.g., small vessel occlusion (SVO) stroke. While hypertension is the leading risk factor for SVO strokes, the link between elevated LDL-cholesterol and SVO stroke is also recognized. Establishing optimal LDL-cholesterol targets for SVO stroke would significantly enhance secondary prevention strategies and improve patient outcome. Thus, the investigators aim to compare intensive versus standard lipid-lowering in patients with SVO stroke. SVO70 is a multicenter, prospective, randomized, open, blinded-endpoint clinical trial. Adult participants with objectively confirmed SVO stroke within 180 days of randomization will be included. Exclusion criteria include those with predefined LDL-cholesterol targets for other conditions, statin contraindications, or women who are pregnant, breastfeeding, or planning pregnancy during the study period. Eligible participants will be randomized 1:1 to target LDL-cholesterol \<70 mg/dL (intensive group) or 90-110 mg/dL (standard group). The trial pl…
This description comes directly from the study's public registry record.
Wookjin Yang, MD, PhD · +82-70-4352-2482 · ywj_2002@naver.com
Seung-Hoon Lee, MD, PhD · +82-2-2072-1014
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| Korea University Ansan Hospital | Ansan, South Korea | Recruiting |
| Hallym University Sacred Heart Hospital | Anyang, South Korea | Recruiting |
| Pusan National University Hospital | Busan, South Korea | Recruiting |
| Gyeongsang National University Changwon Hospital | Changwon, South Korea | Recruiting |
| Samsung Changwon Hospital | Changwon, South Korea | Recruiting |
| Chungbuk National University Hospital | Cheongju-si, South Korea | Recruiting |
| Hallym University Chuncheon Sacred Heart Hospital | Chuncheon, South Korea | Recruiting |
| Kangwon National University Hospital | Chuncheon, South Korea | Recruiting |
| Daegu Catholic University Medical Center | Daegu, South Korea | Recruiting |
| Keimyung University Dongsan Medical Center | Daegu, South Korea | Recruiting |
| Kyungpook National University Chilgok Hospital | Daegu, South Korea | Recruiting |
| Kyungpook National University Hospital | Daegu, South Korea | Recruiting |
+ 34 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06649240