← Eichor
Study identifier: NCT06649058 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active

Condition: Brain Metastases  ·  Sponsor: M.D. Anderson Cancer Center

PhasePhase 2
Planned participants316
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

To learn if consolidative stereotactic radiosurgery (cSRS) can help to control central nervous system (CNS) disease in patients who have brain metastases and have a partial response or stable brain metastases after systemic therapy. To learn if using SRS to treat all brain metastases that do not respond to systemic therapy versus treating only metastases that are getting worse can help to control CNS disease in patients whose disease gets worse after systemic therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Thomas H Bekham, MD,PHD  ·  713-825-3169  ·  thbeckham@mdanderson.org

Always discuss trial participation with your own doctor first.

Locations (1)

The University of Texas MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT06649058