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Study identifier: NCT06647940 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Orelabrutinib in Combination with R-CHOP for CD5-positive DLBCL Patients(Rocket Trial)

Condition: Diffuse Large B Cell Lymphoma (DLBCL)  ·  Sponsor: Sun Yat-sen University

PhasePhase 2
Planned participants39
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a prospective, single-arm, multicenter, phase II clinical trial to evaluate the efficacy and safety of orelabrutinib combined with the R-CHOP (rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisone) regimen as first-line treatment in CD5-positive diffuse large B-cell lymphoma (DLBCL) patients.

This description comes directly from the study's public registry record.

Talk to the study team

Qingqing Cai, MD. PhD.  ·  02087342823  ·  caiqq@sysucc.org.cn

Yi Xia, MD. PhD.  ·  02087342823  ·  xiayi@sysucc.org.cn

Always discuss trial participation with your own doctor first.

Locations (11)

Sun Yat-sen Universitiy Cancer Center, Sun Yat-Sen University,Guangzhou, China, ChinaRecruiting
Gansu Cancer HospitalLanzhou, Gansu, ChinaRecruiting
Dongguan People's HospitalDongguan, Guangdong, ChinaRecruiting
Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou, Guangdong, ChinaRecruiting
First People's Hospital of GuangzhouGuangzhou, Guangdong, ChinaRecruiting
Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou, Guangdong, ChinaRecruiting
Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou, Guangdong, ChinaRecruiting
First Affiliated Hospital of Shantou University Medical College.Shantou, Guangdong, ChinaRecruiting
Shenzhen People's HospitalShenzhen, Guangdong, ChinaRecruiting
Zhaoqing First People's HospitalZhaoqing, Guangdong, ChinaRecruiting
Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai, Guangdong, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06647940