Condition: Alzheimers Disease · Dementia · Alzheimers Disease, Familial · Sponsor: Washington University School of Medicine
The purpose of this research study is to test the study drug, referred to as remternetug, to determine its effectiveness for the study treatment of asymptomatic (at risk) Alzheimer disease in individuals with AD-causing mutations. This study will also investigate the effects of remternetug on biomarkers (measures of the disease including brain scans, blood and spinal fluid tests), examine safety data to identify any potential benefits or risks, and examine how well participants can tolerate remternetug. Stage 1 will determine if treatment with the study drug prevents or reverses amyloid beta (Aβ) accumulation compared with placebo in participants with dominantly inherited Alzheimer's disease (DIAD). Stage 2 will evaluate the effect of early anti-amyloid treatment on downstream biomarkers of AD in treated participants compared to external control groups.
This description comes directly from the study's public registry record.
Jamie Bartzel · 844-DIANEXR (342-6397) · dianexr@wustl.edu
Ellen Ziegemeier · 844-DIANEXR (342-6397) · dianexr@wustl.edu
Always discuss trial participation with your own doctor first.
| University of Alabama in Birmingham | Birmingham, Alabama, United States | Recruiting |
| University of California San Diego Medical Center | La Jolla, California, United States | Recruiting |
| University of Southern Califonria | Los Angeles, California, United States | Not Yet Recruiting |
| Yale University School of Medicine | New Haven, Connecticut, United States | Recruiting |
| Emory University | Atlanta, Georgia, United States | Recruiting |
| Advocate Lutheran General Hospital | Park Ridge, Illinois, United States | Recruiting |
| Indiana University School of Medicine | Indianapolis, Indiana, United States | Recruiting |
| Washington University in St. Louis | St Louis, Missouri, United States | Recruiting |
| New York University Medical Center | New York, New York, United States | Recruiting |
| University of Pittsburgh | Pittsburgh, Pennsylvania, United States | Recruiting |
| Butler Hospital | Providence, Rhode Island, United States | Recruiting |
| Kerwin Research and Memory Center | Dallas, Texas, United States | Recruiting |
+ 25 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06647498