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Study identifier: NCT06644183 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Roginolisib (IOA-244) With Venetoclax and Rituximab for Refractory/Relapsed Chronic Lymphocytic Leukemia (CLL)

Condition: Leukemia · Relapsed Leukemia · Chronic Lymphocytic Leukemia  ·  Sponsor: Jennifer R. Brown, MD, PhD

PhasePhase 1/Phase 2
Planned participants64
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This research study will test the safety and anticancer activity of the combination of three drugs (Roginolisib, Venetoclax, and Rituximab) for participants with relapsed or refractory Chronic Lymphocytic Leukemia (CLL). The names of the study drugs involved in this study are: * Roginolisib (a novel type of PI3-kinase delta inhibitor) * Venetoclax (a type of B-cell lymphoma 2 inhibitor) * Rituximab (a type of monoclonal antibody)

This description comes directly from the study's public registry record.

Talk to the study team

Hang Phan, BS  ·  857-215-1258  ·  hang_phan@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06644183