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Study identifier: NCT06643845 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Is Non Surgical CaRE Using Treat to Target Multimodal meDIcal Strategies aBLE to Delay or Avoid Total Knee Replacement?

Condition: Osteoarthritis, Knee  ·  Sponsor: University Hospital, Brest

PhaseNA
Planned participants1000
Who can joinAll sexes, 18 Years to 90 Years
Healthy volunteersNo

About this study

Knee is the most common site of osteoarthritis. Treatment of knee osteoarthritis starts with a full course of medical therapy, followed by surgery to replace the knee with a prosthesis if this strategy fails, or in advanced cases. However, the new recommendations of the French rheumatology society, which evaluate the various treatments and position them in the treatment plan, are not well known, and the definition of a complete treatment remains unclear. The vast majority of patients are therefore referred to a surgeon after having tried a small part of the therapeutic arsenal (generally analgesics and corticosteroid or hyaluronic acid infiltrations). The goal of this study is to to select patients most likely to gain from surgery and to develop strategies that avoid the need for major surgery.

This description comes directly from the study's public registry record.

Talk to the study team

Alain Saraux, Pr  ·  +33 2 98 34 72 70  ·  alain.saraux@chu-brest.fr

Always discuss trial participation with your own doctor first.

Locations (21)

CHU AmiensAmiens, FranceNot Yet Recruiting
CHU BrestBrest, FranceRecruiting
CHU CaenCaen, FranceNot Yet Recruiting
CHD VendéeLa Roche-sur-Yon, FranceNot Yet Recruiting
CHU Le MansLe Mans, FranceNot Yet Recruiting
CHU LimogesLimoges, FranceNot Yet Recruiting
GHICL- Hôpital Saint PhilibertLomme, FranceNot Yet Recruiting
HCLLyon, FranceNot Yet Recruiting
CHU MontpellierMontpellier, FranceNot Yet Recruiting
CH MorlaixMorlaix, FranceNot Yet Recruiting
CHU NantesNantes, FranceNot Yet Recruiting
CHU NiceNice, FranceNot Yet Recruiting

+ 9 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06643845