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Study identifier: NCT06642272 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record

Condition: Diabetes Mellitus, Type 2 · Heart Failure · Chronic Kidney Diseases  ·  Sponsor: Herlev and Gentofte Hospital

PhasePhase 4
Planned participants17200
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The aim of this clinical trial is investigate the comparative effectiveness of empagliflozin and dapagliflozin for the treatment of diabetes, chronic kidney disease, and heart failure. Patients who are prescribed either empagliflozin or dapagliflozin, as part of daily clinical practice at the participating sites, will be included in the study. Treatment will be randomized automatically through the electronic health record software in clusters defined by time of day. https://www.appletreestudy.com

This description comes directly from the study's public registry record.

Talk to the study team

Morten Schou, Professor  ·  004540523920  ·  morten.schou.04@regionh.dk

Daniel M. Christensen, MD, PhD  ·  004526248546  ·  dmc@dadlnet.dk

Always discuss trial participation with your own doctor first.

Locations (12)

Bispebjerg HospitalCopenhagen, DenmarkRecruiting
RigshospitaletCopenhagen, DenmarkRecruiting
Herlev and Gentofte HospitalHerlev, DenmarkRecruiting
Steno Diabetes Center CopenhagenHerlev, DenmarkRecruiting
Nordsjællands HospitalHillerød, DenmarkRecruiting
Holbæk SygehusHolbæk, DenmarkRecruiting
Hvidovre HospitalHvidovre, DenmarkRecruiting
Sjællands UniversitetshospitalKøge, DenmarkRecruiting
Nykøbing F. SygehusNykøbing Falster, DenmarkRecruiting
Sjællands UniversitetshospitalRoskilde, DenmarkRecruiting
Bornholms HospitalRønne, DenmarkRecruiting
Slagelse SygehusSlagelse, DenmarkRecruiting

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Source record: clinicaltrials.gov/study/NCT06642272