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Study identifier: NCT06641414 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Lisaftoclax (APG-2575) Combined With Azacytidine (AZA) in the Treatment of Patients With Higher-risk Myelodysplastic Syndrome (GLORA-4).

Condition: Higher-risk Myelodysplastic Syndrome  ·  Sponsor: Ascentage Pharma Group Inc.

PhasePhase 3
Planned participants490
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

A global multicenter, randomized, double-blind, placebo-controlled, pivotal phase III study. To evaluate overall survival (OS) of Lisaftoclax (APG-2575) combined with azacitidine (AZA) vs. placebo combined with azacitidine in newly diagnosed patients with HR-MDS.

This description comes directly from the study's public registry record.

Talk to the study team

Yifan Zhai, M.D., Ph.D.  ·  +86-20-28068501  ·  yzhai@ascentage.com

Qian Niu, M.D.  ·  Qian.Niu@ascentage.com

Always discuss trial participation with your own doctor first.

Locations (2)

MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
Peking University People's HospitalBeijing, Beijing Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06641414