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Study identifier: NCT06638931 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Agnostic Therapy in Rare Solid Tumors

Condition: Urachal Cancer · Parathyroid Carcinoma · Fibrolamellar Carcinoma  ·  Sponsor: Instituto do Cancer do Estado de São Paulo

PhasePhase 2
Planned participants28
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The ANTARES study is a phase II basket trial designed to evaluate the tissue-agnostic efficacy of the monoclonal anti-PD1 antibody, nivolumab, in patients with advanced or metastatic rare tumors. The study aims to treat rare malignancies with PD-L1 expression (CPS ≥ 10), regardless of the tumor's tissue type or location. Patients who have not responded to standard treatments will be included, and treatment will last for up to 12 months. The study will assess objective response, progression-free survival, and biomarkers such as PD-L1, ctDNA, and microvesicles, in a multicenter collaborative effort to provide innovative therapeutic options for this underrepresented population

This description comes directly from the study's public registry record.

Talk to the study team

Camila MV Moniz, Doctor  ·  + 55 11 3893-3925  ·  camila.venchiarutti@hc.fm.usp.br

Raelson Miranda, Doctor  ·  + 55 11 3893-3566  ·  raelson.m@hc.fm.usp.br

Always discuss trial participation with your own doctor first.

Locations (8)

Hospital São CarlosFortaleza, Ceará, BrazilNot Yet Recruiting
Hospital São RafaelSalvador, Estado de Bahia, BrazilNot Yet Recruiting
Hospital Santa CruzCuritiba, Paraná, BrazilNot Yet Recruiting
IDOR RecifeRecife, Pernambuco, BrazilNot Yet Recruiting
Instituto D'or de Pesquisa e EnsinoSão Paulo, São Paulo, BrazilRecruiting
Instituto do Câncer do Estado de São Paulo - ICESPSão Paulo, São Paulo, BrazilRecruiting
DF StarBrasília, BrazilNot Yet Recruiting
Instituto D'Or de Pesquisa e EnsinoRio de Janeiro, BrazilNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06638931