Condition: Locally Advanced Triple Negative Breast Cancer · TNBC - Triple-Negative Breast Cancer · Sponsor: Rima Patel
Pilot trial of the IL-4 receptor antagonist dupilumab plus pembrolizumab, paclitaxel, and carboplatin in locally advanced triple negative breast cancer (TNBC). Primary Objective: To assess the safety of neoadjuvant dupilumab and pembrolizumab plus weekly paclitaxel and carboplatin as measured by the proportion of severe immune-related adverse events (irAEs) in patients with locally advanced TNBC. Secondary Objectives: To determine the rates of pathologic complete response with the addition of dupilumab to NAC and pembrolizumab; to determine the rate of residual cancer burden 0-1; to estimate the recurrence-free survival and overall survival; to assess the toxicity of the combination of dupilumab, pembrolizumab, and paclitaxel-carboplatin.
This description comes directly from the study's public registry record.
Rima Patel, MD · (212) 604-6010 · Rima.Patel2@mssm.edu
Katherine Vandris · Katherine.Vandris@mssm.edu
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| Mount Sinai Health System | New York, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06637306