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Study identifier: NCT06634875 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Isunakinra Alone and in Combination With Pembrolizumab in Patients With Colorectal Cancer (MSS)

Condition: Colorectal Cancer Metastatic  ·  Sponsor: Buzzard Pharmaceuticals

PhasePhase 2
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will enroll patients with colorectal cancer that is locally advanced or metastatic. The tumor must be microsatellite stable (MSS), have a tumor mutational burden that is high (TMB-H) and be kras mutated. Patients must have been treated with available approved treatments already. In this study the investigators are testing a new type of immunotherapy, the potent IL-1 inhibitor isunakinra to be added to already approved immunotherapy (PD-1/PD-L1 inhibitor) in an attempt to get this treatment to work in this treatment resistant type of tumor.

This description comes directly from the study's public registry record.

Talk to the study team

Maarten de Chateau, MD PhD  ·  +46 763 103031  ·  info@buzzardpharma.com

Hans Olivecrona, MD PhD  ·  info@buzzardpharma.com

Always discuss trial participation with your own doctor first.

Locations (2)

USC/Norris Cancer CenterLos Angeles, California, United StatesRecruiting
Hoag Memorial Hospital PresbyterianNewport Beach, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06634875