Condition: Healthy Control · Depression · Sponsor: Jing Jiang
The goal of this clinical trial is to examine the neural mechanisms underlying transcranial magnetic stimulation (TMS) using concurrent functional magnetic resonance imaging (fMRI) in both healthy controls (HCs) and patients with high negative affect symptoms, such as depression. Approximately half male and half female participants aged 18-65 will be recruited. The main questions it aims to answer are: 1. Is the acute/transient effect induced by single-pulse TMS related to the long-term modulatory effect induced by repetitive TMS (rTMS)? 2. Do any of these effects predict negative affect symptoms, such as depression? Participants will: 1. Complete several tests to assess their cognitive abilities and emotional states 2. Undergo several brain scans, including resting-state fMRI, structural MRI, diffusion tensor imaging (DTI), and task fMRI 3. Have two different types of TMS sequences, single-pulse and repetitive pulses, administered to specific brain regions while undergoing fMRI
This description comes directly from the study's public registry record.
Jing Jiang, PHD · 319-678-3410 · TMS-fMRI-Study@uiowa.edu
Emily Gittle, BS · 319-678-7043 · TMS-fMRI-Study@uiowa.edu
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| University of Iowa Carver College of Medicine | Iowa City, Iowa, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06633913