Condition: Dilated Cardiomyopathy · Sponsor: National Taiwan University Hospital
Brief Summary(Use lay language. Include a statement of the study hypothesis.): Dilated cardiomyopathy (DCM) is the most common childhood cardiomyopathy and is associated with significant early morbidity and mortality. Those who fail to improve within the first year of diagnosis usually deteriorated even upon aggressive anti-congestive medications. Investigators had conducted precision-medicine-based approach to provide strategic approach as drug repurposing to identify new treatments. Investigators have identified the beneficial effects from a statin, simvastatin, to restore the cardiac contractility in the human induced pluripotent stem cell lines derived from a DCM proband and the proband's father. The mutant mouse consequently confirmed the beneficial effects. The initial experience in the proband is promising. This clinical trial is to find out if simvastatin will benefit the cardiac function of DCM patients.
This description comes directly from the study's public registry record.
Wei-Chieh Tseng · 0972652584 · littlecardiologist@gmail.com
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| National Taiwan University Hospital | Taipei County, Zhongzheng District, Taiwan | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06632834