Condition: Diuretics Drug Reactions · Heart Failure; With Decompensation · Albumin; Double · Sponsor: Democritus University of Thrace
Patients hospitalized for acute decompensation of CHF are usually complicated by worsening renal function (WRF) which leads to diuretic resistance and inadequate decongestion as well as poor prognosis. WRF has been attributed to a reflex renal vasoconstriction elicited by intravascular volume depletion during brisk diuresis. The investigators hypothesize that CHF patients with hepatic dysfunction are more prone to WRF due to poor albumin production. This sub-group of CHF patients may benefit more (increased diuretic efficacy and protected against worsening renal function) by the use of IV loop diuretics in combination with an intravascular volume expander such as IV Human Albumin.
This description comes directly from the study's public registry record.
MARIOS-VASILEIOS A KOUTROULOS · +30 6942862493 · mvkoutroulos@gmail.com
ANARGYROS TSALGKIDIS · 6940926983 · anargyrost@gmail.com
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| DUThrace Cardiology Department | Alexandroupoli, Evros, Greece | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06630923