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Study identifier: NCT06630884 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Inflammatory Challenge and Fear

Condition: Posttraumatic Stress Disorder (PTSD)  ·  Sponsor: University of California, San Francisco

PhasePhase 1
Planned participants288
Who can joinAll sexes, 18 Years to 60 Years
Healthy volunteersYes

About this study

The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are: Do people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who receive typhoid vaccine experience changes in how they think and feel? Participants will: Attend four appointments at the San Francisco VA Health Care System; Receive typhoid vaccine or placebo at one of the visits; Have their physiological responding measured while listening to sounds; Complete questionnaires and psychological tests.

This description comes directly from the study's public registry record.

Talk to the study team

Aoife O'Donovan, PhD  ·  415-221-4810  ·  aoife.odonovan@ucsf.edu

Michael Srouji, BA  ·  415-221-4810

Always discuss trial participation with your own doctor first.

Locations (1)

San Francisco VA Health Care SystemSan Francisco, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06630884