Condition: Lymphoproliferative Disorder · Multiple Myeloma · Sponsor: Mayo Clinic
This clinical trial evaluates the impact of preexisting and therapy-emergent germline and somatic variants on cytopenia in patients with multiple myeloma or CD19 positive lymphoproliferative disorder (LPD) following chimeric antigen receptor T-cell (CAR-T) therapy. The most common adverse event after CAR-T therapy is lower than normal blood cells (cytopenia) and up to one third of patients experience cytopenia that last longer than 30 days post-infusion. Germline and somatic variants are changes in genes found using cancer genomic tests. Cancer genetic/genomic testing is a series of tests that find specific changes in cancer cells or in blood deoxyribonucleic acid. Identifying gene mutations may help identify the risk of cytopenia in patients with multiple myeloma or CD19 positive LPD following CAR-T therapy.
This description comes directly from the study's public registry record.
Clinical Trials Referral Office · 855-776-0015 · mayocliniccancerstudies@mayo.edu
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| Mayo Clinic in Arizona | Scottsdale, Arizona, United States | Recruiting |
| Mayo Clinic in Florida | Jacksonville, Florida, United States | Recruiting |
| Mayo Clinic Health System in Albert Lea | Albert Lea, Minnesota, United States | Recruiting |
| Mayo Clinic Health System-Mankato | Mankato, Minnesota, United States | Recruiting |
| Mayo Clinic in Rochester | Rochester, Minnesota, United States | Recruiting |
| Mayo Clinic Health System-Eau Claire Clinic | Eau Claire, Wisconsin, United States | Recruiting |
| Mayo Clinic Health System-Franciscan Healthcare | La Crosse, Wisconsin, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06630104