Condition: Melanoma · Immunotoxicity · Sponsor: University Hospital, Montpellier
Management of melanoma is based on primary excision of the tumor. In cases of melanoma with poor prognosis criteria, or when it is locally advanced or metastatic, there is an indication for the implementation of adjuvant therapy, which may, in this context, be immunotherapy. Immunotherapies are treatments that have revolutionized the prognosis of patients with melanoma. These are therapies that work by stimulating the immune system to enhance the anti-tumor response. Their toxicities are represented by immune-mediated toxicities, similar to true autoimmune diseases. Adapted physical activity as supportive care in oncology is expanding. From a pathophysiological perspective, physical activity is thought to modulate the immune system (by reducing inflammation, restoring immune surveillance, stimulating anti-tumor responses through the induction of T cell proliferation, modulating the gut microbiota, and influencing tumor microenvironment cells, etc.). The modulation of the immune system by physical activity may also allow us to hypothesize a modulation of the toxicities induced by immune checkpoint inhibitors. We wish to study this hypothesis in patients with advanced melanoma who are candidates for immunotherapy. Originality and Innovative Aspects: Physical activity as supportive care in oncology has developed significantly in recent years. However, adapted physical activity (APA) is currently only offered at one center in France (CHU de Lille). In addition to the probab…
This description comes directly from the study's public registry record.
Alexandre Maria, MD, PhD · 00330665849253 · a-maria@chu-montpellier.fr
Quentin Samaran, MD, MSc · 00330467336906 · q-samaran@chu-montpellier.fr
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| CHU de Montpellier | Montpellier, France | Recruiting |
| Institut du Cancer de Montpellier (ICM) | Montpellier, France | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06627595