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Study identifier: NCT06626789 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Brain Signal Training to Enhance Affect Down-regulation

Condition: Borderline Personality Disorder  ·  Sponsor: Central Institute of Mental Health, Mannheim

PhasePhase 1/Phase 2
Planned participants164
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

Individuals with Borderline Personality Disorder (BPD) experience intensive, instable negative emotions. Hyperactivity of the amygdala is assumed to drive exaggerated emotional responses in BPD. Neurofeedback is an endogenous neuromodulation method to address the imbalance of neural circuits. Downregulation of amygdala hyperactivation with neurofeedback may ameliorate dysregulated emotions in BPD. The BrainSTEADy trial is designed to determine whether amygdala-fMRI-BOLD neurofeedback has a specific effect on affect instability in BPD beyond nonspecific benefit.

This description comes directly from the study's public registry record.

Talk to the study team

Christian Paret-Voigt, Dr.  ·  +4962117034462  ·  christian.paret@zi-mannheim.de

Miroslava Hofmanová  ·  +4962117034463  ·  miroslava.hofmanova@zi-mannheim.de

Always discuss trial participation with your own doctor first.

Locations (6)

University clinic FreiburgFreiburg im Breisgau, GermanyRecruiting
University clinic GiessenGiessen, GermanyRecruiting
University Clinic Halle (Saale)Halle, GermanyNot Yet Recruiting
University Medical Center Hamburg-EppendorfHamburg, GermanyRecruiting
Central Institute of Mental HealthMannheim, GermanyRecruiting
University Clinic TuebingenTübingen, GermanyRecruiting

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Source record: clinicaltrials.gov/study/NCT06626789