● Recruiting

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

Condition: Solid Tumor, Adult · Metastatic Breast Cancer · Advanced Breast Cancer · Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

PhasePhase 1

Planned participants392

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

First in human study to evaluate the safety, tolerability, and pharmacokinetics (PK) of BBO-10203, a PI3Kα:RAS breaker, alone and in combination with other anti-cancer agents in patients with advanced solid tumors.

This description comes directly from the study's public registry record.

Talk to the study team

BBOT (BridgeBio Oncology Therapeutics) · 650-405-8440 · Breaker-101ct.gov@bridgebiooncology.com

Always discuss trial participation with your own doctor first.

Locations (40)

City of Hope Comprehensive Cancer Center	Duarte, California, United States	Recruiting
University of California Los Angeles	Los Angeles, California, United States	Recruiting
University of California San Diego Moores Cancer Center	San Diego, California, United States	Recruiting
UCSF Helen Diller Family Comprehensive Cancer Center	San Francisco, California, United States	Recruiting
Moffitt Cancer Center	Tampa, Florida, United States	Recruiting
Indiana University Simon Comprehensive Cancer Center	Indianapolis, Indiana, United States	Recruiting
Massachusetts General Hospital	Boston, Massachusetts, United States	Recruiting
Dana-Farber Cancer Insitute	Boston, Massachusetts, United States	Recruiting
St. Lukes Hospital of Kansas City	Kansas City, Missouri, United States	Recruiting
Washington University School of Medicine	St Louis, Missouri, United States	Recruiting
Columbia University Irving Medical Center	New York, New York, United States	Recruiting
Memorial Sloan Kettering Cancer Center	New York, New York, United States	Recruiting

+ 28 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06625775