Condition: Heart Transplant · Cardiovascular Disease · Kidney Disease · Sponsor: VA Office of Research and Development
Heart transplant (HTx) is an established therapy for advanced heart disease that restores quality of life and improves survival. However, due to preexisting comorbidities combined with the immunosuppressive therapies required after transplantation, HTx recipients remain at high risk for kidney, cardiovascular (CV), and metabolic disease. Large randomized clinical trials have recently shown that sodium-glucose cotransporter 2 inhibitors (SGLT2i) have potent kidney protective and CV benefits in many populations of patients with chronic kidney disease (CKD), CV disease and/or diabetes. SGLT2i have not been studied prospectively in HTx recipients, which represents a barrier to their use in this population. In this multicenter randomized controlled trial in Veterans with HTx, investigators will evaluate the potential benefits of empagliflozin on kidney function, cardiometabolic risk, erythropoiesis, and functional status. A total of 200 Veterans will be randomly assigned to receive either empagliflozin 10 mg daily or a matching placebo for 12 months.
This description comes directly from the study's public registry record.
Heather Hanson, AAS BS · (801) 582-1565 · Heather.Hanson@va.gov
Josef Stehlik, MD MPH · (801) 582-1565 · josef.stehlik@va.gov
Always discuss trial participation with your own doctor first.
| VA Palo Alto Health Care System, Palo Alto, CA | Palo Alto, California, United States | Not Yet Recruiting |
| Tennessee Valley Healthcare System Nashville Campus, Nashville, TN | Nashville, Tennessee, United States | Not Yet Recruiting |
| Michael E. DeBakey VA Medical Center, Houston, TX | Houston, Texas, United States | Not Yet Recruiting |
| VA Salt Lake City Health Care System, Salt Lake City, UT | Salt Lake City, Utah, United States | Recruiting |
| Hunter Holmes McGuire VA Medical Center, Richmond, VA | Richmond, Virginia, United States | Not Yet Recruiting |
| William S. Middleton Memorial Veterans Hospital, Madison, WI | Madison, Wisconsin, United States | Not Yet Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06625073