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Study identifier: NCT06623422 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

Condition: Carcinoma, Non-Small-Cell Lung  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants680
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment).

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (238)

Banner MD Anderson Cancer Center ( Site 0181)Gilbert, Arizona, United StatesRecruiting
The University of Arizona Cancer Center - North Campus ( Site 0163)Tucson, Arizona, United StatesRecruiting
Providence St. Jude Medical Center ( Site 0106)Fullerton, California, United StatesRecruiting
VA Long Beach Healthcare System ( Site 0199)Long Beach, California, United StatesRecruiting
USC Norris Comprehensive Cancer Center ( Site 0205)Los Angeles, California, United StatesRecruiting
UCLA Jonsson Comprehensive Cancer Center ( Site 0135)Los Angeles, California, United StatesRecruiting
UCSF Medical Center at Mission Bay ( Site 0178)San Francisco, California, United StatesRecruiting
University of Colorado Anschutz Medical Campus ( Site 0151)Aurora, Colorado, United StatesRecruiting
UCHealth Memorial Hospital Central ( Site 0125)Colorado Springs, Colorado, United StatesRecruiting
Banner MD Anderson Cancer Center at North Colorado Medical Center ( Site 0207)Greeley, Colorado, United StatesRecruiting
Centura Health - St. Anthony North Health Campus ( Site 0189)Westminster, Colorado, United StatesRecruiting
Yale University School of Medicine ( Site 0201)New Haven, Connecticut, United StatesRecruiting

+ 226 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06623422