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Study identifier: NCT06621914 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Is Low-load Resistance Training With Blood Flow Restriction Feasible During Rehabilitation of Military Personnel With Lower Limb Injuries? Phase One RCT.

Condition: Pain · Persistent Pain · Musculoskeletal Pain  ·  Sponsor: Defence Medical Rehabilitation Centre, UK

PhaseNA
Planned participants28
Who can joinAll sexes, 18 Years to 55 Years
Healthy volunteersNo

About this study

Pain can be one of the primary limiting factors to progress following musculoskeletal injury and may be caused by trauma or degenerative changes. There are few exercise rehabilitation interventions able to relieve pain, thereby reducing the number of military personnel fit for operations. Low load blood flow restriction (BFR) exercise has been shown to elicit an analgesic response and promote beneficial physiological changes in a variety of clinical populations. This two phase study, aims to: * Determine the most effective and feasible BFR resistance exercise protocol for reducing pain in UK military patients. * Determine the efficacy of an optimal BFR exercise protocol for reducing pain and improving rehabilitation outcomes in UK military patients. * Identify key physiological mechanisms underpinning any beneficial effect of BFR exercise on pain. Consequently, results from this study will have direct clinical application and will aid best practice guidelines for the management of pain across Defence Rehabilitation by influencing the future rehabilitation paradigm. The investigators believe the results and impact will be far reaching, providing invaluable insight and knowledge to the clinical and scientific community to not only those embedded within Defence Rehabilitation, but also those working in civilian sector organisations and professional sport also.

This description comes directly from the study's public registry record.

Talk to the study team

Peter Ladlow, PhD  ·  +44 1509 251 500  ·  peter.ladlow100@mod.gov.uk

Luke Hughes, PhD  ·  luke4.hughes@northumbria.ac.uk

Always discuss trial participation with your own doctor first.

Locations (1)

Defence Medical Rehabilitation Centre, Stanford HallLoughborough, Leicestershire, United KingdomRecruiting

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Source record: clinicaltrials.gov/study/NCT06621914