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Study identifier: NCT06621121 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Real-world Study of Tenecteplase Versus Alteplase for Thrombolysis in Patients Within 4.5 H of Onset of Ischemic Stroke

Condition: Stroke Acute · Tenecteplase · Alteplase  ·  Sponsor: Tianjin Huanhu Hospital

PhaseN/A
Planned participants6000
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Stroke is the second leading cause of death worldwide, killing nearly 7 million people every year. Acute ischemic stroke is caused by focal cerebral hypoperfusion, usually due to embolism or atherosclerotic disease . Ischemic strokes account for 60-70% of all strokes worldwide and are severely debilitating, drawing considerable attention due to their high prevalence.The majority of studies comparing the efficacy and safety of teneplase and alteplase are predominantly randomized controlled trials with limited representation from real-world studies.The aim of this study is to compare the safety, efficacy and economic benefits of recombinant human TNK tissue plasminogen activator (tenecteplase, rhTNK-tPA, TNK) and recombinant tissue plasminogen activator (alteplase, rtPA) in clinical practice. This study aimed to establish a foundation for refining intravenous thrombolytic therapy tailored to various patient profiles and to guide clinicians in selecting the most suitable thrombolytic treatment options.

This description comes directly from the study's public registry record.

Talk to the study team

Shoufeng Liu, MD  ·  400-802-7885  ·  shoufengliu2010@163.com

Yalin Guan, MD  ·  400-802-7885  ·  guanyalinhh@126.com

Always discuss trial participation with your own doctor first.

Locations (1)

Tianjin Huanhu HospitalTianjin, Tianjin Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06621121