Condition: NSCLC · Sponsor: Groupe Francais De Pneumo-Cancerologie
The goal of this clinical trial is to learn if the treatment by systemic Brigatinib (ALUNBRIG®) associated to local ablative therapy (LAT) treatment is improved if administered when the brigatinib works best in participants presenting an advanced non-small cells lung cancer with an ALK gene anomaly (this anomaly produces a defective protein that is responsible for the multiplication of cancer cells). This clinical trial is expected to involve 45 participants in several sites in France. Advanced non-small cell lung cancer (NSCLC) participants with ALK rearrangements treated with brigatinib in first line of non-curable setting will be screened. If the disease assessment done between 3 to 9 months after initiation of brigatinib shows: * a tumor response or stabilization (according to RECIST 1.1) * a disease which meets the definition of an oligometastatic disease (five metastatic lesions or less and a maximum of two lesions per organ) * all tumor targets are accessible to a local ablative therapy (confirmed by an expert panel of clinicians before inclusion): surgery, stereotactic radiosurgery (SRS). For liver, adrenal, or other metastases, percutaneous thermal ablation will be accepted. Participants will be asked to visit the clinic: * for eligibility criteria assessment prior to LAT * for LAT * every 8 weeks for checkups and tests the first year after LAT * and then every 12 weeks, for a maximum period of 3 years. Eligible patients will benefit from local ablative therap…
This description comes directly from the study's public registry record.
Hubert CURCIO · +330231455160 · h.curcio@baclesse.unicancer.fr
Soizic FERLANDIN · +330663224789 · soizic_ferlandin@yahoo.fr
Always discuss trial participation with your own doctor first.
| CHU de Brest | Brest, France | Not Yet Recruiting |
| Centre François Baclesse | Caen, France | Not Yet Recruiting |
| CH Métropole-Savoie | Chambéry, France | Not Yet Recruiting |
| Hôpital Louis Pasteur | Colmar, France | Not Yet Recruiting |
| Pneumologie Centre Hospitalier Intercommunal de Créteil | Créteil, France | Not Yet Recruiting |
| Centre Georges-François Leclerc | Dijon, France | Not Yet Recruiting |
| CH Annecy | Épagny, France | Not Yet Recruiting |
| Polyclinique de Blois | La Chaussée-Saint-Victor, France | Not Yet Recruiting |
| CHD les Oudaries | La Roche-sur-Yon, France | Not Yet Recruiting |
| CHU Dupuytren | Limoges, France | Not Yet Recruiting |
| Centre Leon Bérard | Lyon, France | Withdrawn |
| Hôpital Nord | Marseille, France | Not Yet Recruiting |
+ 15 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06620835