Condition: Obesity; Drug · Obesity, Morbid · Sponsor: Laval University
The goal of this clinical trial is to assess the impact of combination therapy with Naltrexone-Bupropion (NB) in the post-operative period of sleeve gastrectomy (SG). on a) weight loss, b) resolution of comorbidities and c) eating behaviors. Researchers will compare SG-NB group with SG-placebo group to see if they experience significantly higher excess weight loss (EWL) at 12 and 24 months and if there is a significantly higher percentage of patients with an EWL above 50% in the SG-NB group versus in the SG-placebo group. Participants will be randomized 1:1 to SG in combination with NB versus SG with placebo. Patients will be started one month after surgery on a progressive dose of Naltrexone/Bupropion extended-release or placebo. Duration of therapy will be 24 months.Both groups will benefit from behavioral and nutritional support.
This description comes directly from the study's public registry record.
Mélanie Nadeau · 4186568711 · melanie.nadeau@criucpq.ulaval.ca
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| Criucpq-Ul | Québec, Quebec, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06620562