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Study identifier: NCT06619587 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors

Condition: Solid Tumor  ·  Sponsor: Genentech, Inc.

PhasePhase 1
Planned participants410
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a first-in-human Phase I/II, open-label, multicenter, dose-escalation and expansion study designed to evaluate the safety, pharmacokinetics, and preliminary activity of GDC-7035 as a single agent and in combination with other anti-cancer therapies in participants with advanced or metastatic solid tumors that harbor the KRAS G12D mutation.

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: GO45416 https://forpatients.roche.com/ No attachments to email below.  ·  888-662-6728 (U.S.)  ·  global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Always discuss trial participation with your own doctor first.

Locations (41)

UC San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting
Sarah Cannon Research Institute at HealthONEDenver, Colorado, United StatesRecruiting
Yale Cancer CenterNew Haven, Connecticut, United StatesRecruiting
Florida Cancer Specialist-Lake MaryLake Mary, Florida, United StatesCompleted
University of IllinoisChicago, Illinois, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
START - Midwest - EDOSGrand Rapids, Michigan, United StatesRecruiting
Montefiore Einstein Cancer CenterThe Bronx, New York, United StatesRecruiting
Mary Crowley Medical Research CenterDallas, Pennsylvania, United StatesRecruiting
Abramson Cancer Center;Univ of PennsylvaniaPhiladelphia, Pennsylvania, United StatesRecruiting
SCRI Oncology PartnersNashville, Tennessee, United StatesRecruiting
O'Quinn Medical Tower at McNair CampusHouston, Texas, United StatesRecruiting

+ 29 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06619587