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Study identifier: NCT06619301 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

RCT Glargine vs NPH for Treatment of DM in Pregnancy

Condition: Diabetes Mellitus in Pregnancy · Type 2 Diabetes Mellitus (T2DM) · Gestational Diabetes Mellitus, Class A2  ·  Sponsor: Loyola University

PhasePhase 3
Planned participants160
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

We are asking you to take part in this research study because you are diagnosed with pregestational Type 2 Diabetes Mellitus or Gestational Diabetes Mellitus requiring insulin therapy in pregnancy. Currently, many hospitals differ among use of insulin for management of DM in pregnancy, with NPH, glargine and detemir being the most commonly used forms of basal insulin. Outside of pregnancy, NPH is rarely used with glargine and determir being the more common forms of insulin used due to their fewer episodes of hypoglycemia in these patients. Detemir has been well studied in pregnancy and found to be noninferior to NPH. Unfortunately, glargine has not been as well studied in pregnancy. Thus, with this study we want to compare glargine and NPH. The purpose of this study is to compare two different forms of insulin (Glargine and NPH) that we regularly use to manage diabetes mellitus in pregnancy.

This description comes directly from the study's public registry record.

Talk to the study team

Joana Lopes Perdigao, MD  ·  708-216-4033  ·  joana.perdigao@lumc.edu

Nuong Truong, MD  ·  708-216-4033  ·  nuong.t.truong@luhs.org

Always discuss trial participation with your own doctor first.

Locations (1)

Loyola University Medical CenterMaywood, Illinois, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06619301