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Study identifier: NCT06617793 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

An Open-label Study to Assess the Safety, Efficacy, and Cellular Kinetics of YTB323 in Relapsing Multiple Sclerosis

Condition: Relapsing Multiple Sclerosis  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 1/Phase 2
Planned participants28
Who can joinAll sexes, 18 Years to 60 Years
Healthy volunteersNo

About this study

This is an open-label, multi-center, non-confirmatory study to assess the safety, efficacy, and cellular kinetics of YTB323 in approximately 28 participants with Relapsing Multiple Sclerosis (RMS) with breakthrough disease activity during previous treatment with a highly efficacious therapy (BD-HET). The study design utilizes an ascending single dose design consisting of 3 sentinel cohorts followed by an expansion cohort.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  +41613241111  ·  novartis.email@novartis.com

Novartis Pharmaceuticals

Always discuss trial participation with your own doctor first.

Locations (18)

Novartis Investigative SiteDarlinghurst, New South Wales, AustraliaRecruiting
Novartis Investigative SiteMelbourne, Victoria, AustraliaRecruiting
Novartis Investigative SiteMontpellier, FranceRecruiting
Novartis Investigative SiteNancy, FranceRecruiting
Novartis Investigative SiteRennes, FranceRecruiting
Novartis Investigative SiteBochum, GermanyRecruiting
Novartis Investigative SiteEssen, GermanyRecruiting
Novartis Investigative SiteMainz, GermanyRecruiting
Novartis Investigative SiteUlm, GermanyRecruiting
Novartis Investigative SiteGenova, GE, ItalyRecruiting
Novartis Investigative SiteMilan, MI, ItalyRecruiting
Novartis Investigative SiteBarcelona, SpainRecruiting

+ 6 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06617793