Condition: Solid Tumor, Adult · Bladder Cancer · Urothelial Carcinoma · Sponsor: Monopar Therapeutics
This is an open-label, uncontrolled, multi-center, phase 1a MNPR-101-PCTA-177Lu dose-escalation study in patients with solid tumor cancers. Patients must have participated in the imaging study MNPR-101-D001 (actively recruiting, diagnostic study of MNPR-101-DFO\*-89Zr). * TITE-BOIN will be used to objectively determine dose increase, no dose change, or dose decrease for each group of two patients. * The treatment period consists of two 12-week cycles. Patients will receive three equal fractions of MNPR-101-PCTA-177Lu with radioactivity ranging from 480-2240 MBq on each of Cycle 1 Day 1, Cycle 1 Day 15, and Cycle 2 Day 1 (12 weeks after Cycle 1 Day 1). * Patients will be followed for 12 weeks after their last dose of MNPR-101-PCTA-177Lu. * Patients will be imaged at specific timepoints during the study.
This description comes directly from the study's public registry record.
Director Clinical Operations · 847-794-8435 · monitoring@monopartx.com
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| Melbourne Theranostic Innovation Centre (MTIC) | North Melbourne, Victoria, Australia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06617169