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Study identifier: NCT06616766 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase 1/2, Open-label, Multicenter, FIH Study to Evaluate Safety, Tolerability, PK and Anti-tumor Activity of YH42946

Condition: NSCLC (Non-small Cell Lung Cancer) · Solid Tumor  ·  Sponsor: Yuhan Corporation

PhasePhase 1/Phase 2
Planned participants161
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this YH42946-101 is to evaluate the safety, Tolerability, Pharmacokinetics and anti-tumor activity of YH42946 in patients with locally advanced of metastatic solid tumors with HER2 aberration and EGFR exon 20 insertions.

This description comes directly from the study's public registry record.

Talk to the study team

Yuhan Corporation Clinical Operation Team 1  ·  8228280576  ·  clinicaltrials@yuhan.co.kr

Always discuss trial participation with your own doctor first.

Locations (8)

Next Oncology VirginiaFairfax, Virginia, United StatesRecruiting
Seoul National University Bundang HospitalSeongnam-si, Gyeonggi-do, South KoreaRecruiting
The Catholic Univ. of Korea St. Vincent's HospitalSuwon, Gyeonggi-do, South KoreaRecruiting
Chungbuk National University HospitalCheongju-si, North Chungcheong, South KoreaRecruiting
Seoul National University HospitalSeoul, South KoreaRecruiting
Severance Hospital, Yonsei UniversitySeoul, South KoreaRecruiting
Samsung Medical CenterSeoul, South KoreaRecruiting
Asan Medical Center, University of UlsanSeoul, South KoreaRecruiting

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Source record: clinicaltrials.gov/study/NCT06616766