Condition: Atrial Fibrillation (AF) · Sponsor: China National Center for Cardiovascular Diseases
The DESTINATION Study investigates whether anticoagulation therapy is necessary after successful catheter ablation (CA) for atrial fibrillation (AF). Current guidelines recommend continued anticoagulation based on stroke risk scores, even post-ablation, potentially exposing patients to unnecessary bleeding risks. This international, multicenter, randomized controlled trial aims to compare thromboembolic and bleeding event risks between patients who continue and discontinue anticoagulation after ablation. The study involves 3,160 AF patients, all free of AF recurrence within 6 months to 1 year after ablation. Smart wearable monitors will track recurrence, and patients are followed for 24 months to assess event rates. Findings may reshape anticoagulation guidelines, improving clinical practice for AF patients worldwide.
This description comes directly from the study's public registry record.
Yan Yao, PhD · 13901121319 · ianyao@263.net.cn
Lingmin Wu, Phd · wulingmin@fuwai.com
Always discuss trial participation with your own doctor first.
| Brigham and Women Hospital | Boston, Massachusetts, United States | Not Yet Recruiting |
| Beijing Anzhen Hospital | Beijing, Beijing Municipality, China | Not Yet Recruiting |
| Fuwai Hospital | Beijing, Beijing Municipality, China | Recruiting |
| The First Affiliated Hospital, Sun Yat-sen University | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen | Shenzhen, Guangdong, China | Recruiting |
| Fuwai Central China Cardiovascular Hospital | Zhengzhou, Henan, China | Not Yet Recruiting |
| Wuhan Asia Heart Hospital | Wuhan, Hubei, China | Recruiting |
| Shanghai Chest Hospital | Shanghai, Shanghai Municipality, China | Not Yet Recruiting |
| Shanxi Cardiovascular Hospital (Shanxi Cardiovascular Research Institute) | Taiyuan, Shanxi, China | Not Yet Recruiting |
| West China Hospital, Sichuan University | Chengdu, Sichuan, China | Not Yet Recruiting |
| Yunnan Fuwai Cardiovascular Hospital | Kunming, Yunnan, China | Not Yet Recruiting |
| Sir Run Run Shaw Hospital, Zhejiang University School of Medicine | Hangzhou, Zhejiang, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06615596