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Study identifier: NCT06614322 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.

Condition: Painful Peripheral Neuropathy · Diabetic Peripheral Neuropathic Pain (DPN) · Chemotherapy Induced Peripheral Neuropathy (CIPN)  ·  Sponsor: University of Rochester

PhasePhase 2
Planned participants190
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain treatments in participants with painful peripheral neuropathy. The analgesic effect is evaluated by measuring pain intensity and Patient Global Impression of Change (PGIC). This study is a 3-period cross-over trial. This means researchers will compare 3 different drugs (pregabalin, duloxetine, and placebo) over a period of 19 weeks. Participants will: * Undergo a quantitative sensory testing (QST) exam. * Provide a blood sample. * Complete questionnaires on the computer. * Take the study drug as instructed.

This description comes directly from the study's public registry record.

Talk to the study team

Rachel De Guzman  ·  585-275-9361  ·  rachel_deguzman@urmc.rochester.edu

Always discuss trial participation with your own doctor first.

Locations (7)

Beth Israel Deaconess Medical Center for Autonomic and Peripheral Nerve DisordersBoston, Massachusetts, United StatesRecruiting
Ichan School of Medicine at Mount SinaiNew York, New York, United StatesNot Yet Recruiting
University of RochesterRochester, New York, United StatesRecruiting
University of PittsburghPittsburgh, Pennsylvania, United StatesNot Yet Recruiting
University of UtahSalt Lake City, Utah, United StatesNot Yet Recruiting
University of VermontBurlington, Vermont, United StatesRecruiting
VCU Medical CenterRichmond, Virginia, United StatesNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06614322