Condition: Immunodeficiency · Sponsor: University of Cologne
Managing respiratory virus infections in immunocompromised patients requires a multidisciplinary approach, including vaccination, though its effectiveness is often suboptimal in these individuals. In hematological patients, poor humoral immunogenicity is common, especially when the B cell axis is affected by disease or treatment, while T cell responses may offer better protection. Current immunologic data on these patients is limited, focusing mostly on serologic parameters. To address this, we will conduct an observational study analyzing early and late booster vaccinations, with a focus on virus-specific T cell responses in vaccinated patients.
This description comes directly from the study's public registry record.
Sibylle Mellinghoff, MD · +4947885523 · sibylle.mellinghoff@uk-koeln.de
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| University Hospital Cologne | Cologne, North Rhine-Westphalia, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06612515