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Study identifier: NCT06610682 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Trial to Evaluate CSF ctDNA and Safety of Plixorafenib Alone or With Retifanlimab in Patients With BRAF-altered Glioma

Condition: BRAF V600E Mutation  ·  Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

PhaseEARLY_Phase 1
Planned participants24
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The investigators will evaluate the sensitivity of ctDNA from plasma and CSF at baseline (defined as C1D1) and over time in response to treatment with plixorafenib alone or in combination with retifanlimab in patients with BRAF-V600E mutant glioma refractory to prior therapies.

This description comes directly from the study's public registry record.

Talk to the study team

Study Chair, MD  ·  410-955-8837  ·  ksolt1@jhmi.edu

Principal Investigator, MD  ·  410-955-8837

Always discuss trial participation with your own doctor first.

Locations (1)

Johns HopkinsBaltimore, Maryland, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06610682